Project
A Phase I / II Randomised Controlled Study of OGT 918 in Niemann-Pick type C
College of Physicians and Surgeons
Niemann-Pick disease, type C (NPC), is a progressive neurodegenerative disorder in which abnormal intracellular lipid trafficking leads to accumulation of multiple lipids, including . . . More »
|  | Project Leader
Patterson, Marc
| | Location
United Kingdom
|
Project
Assessing the Function of NEK2
College of Physicians and Surgeons
The long-term goal of the research effort is to elucidate the genetic program controlling the mitotic and meiotic divisions of the germ-line cells, with particular consideration of the evolutionary . . . More »
| | Project Leader
Wolgemuth, Debra
| | Location
Korea (south)
|
Project
Cellular Biology of Atherosclerosis
College of Physicians and Surgeons
Cellular biology of atherosclerosis
More »
| | Project Leader
Tabas, Ira
| | Location
United States of America
|
Project
Cellular Immunity to HIV in Infants
Mailman School of Public Health
This is a study to investigate correlates of protective immunity to HIV among infants of HIV-infected mothers in South Africa. The study measures cell-mediated immune responses to HIV antigens in . . . More »
| | Project Leader
Kuhn, Louise
| | Location
South Africa
|
Project
Clinical Gene Therapy Trial at the Pavia Medical Center
College of Physicians and Surgeons
We are providing MDR retriviral producer line for the following experiments: (1) transfer of the multidrug-resistence gene into human hematopoietic progenitors collected from bone marrow, peripheral . . . More »
| | Project Leader
Bank, Arthur
| | Location
Italy
|
Project
Clinical Gene Therapy Trial for Patients with Lymphoma at University College London, UK
College of Physicians and Surgeons
We are providing the MDR-containing retroviral supernatants for the CD34+ cell transduction trial in patients with lymphoma. We are continuing experimentation in improving the efficiency of . . . More »
| | Project Leader
Bank, Arthur
| | Location
United Kingdom
|
Project
Development of Dipeptide That Acts on Serotonin Receptor
College of Physicians and Surgeons
Synthesis of N-acetyl, 5-hydroxytoyptophyl amide. Aspecific inhibitor of gut H tip receptor. . . . More »
| | Project Leader
Tamir, Hadassah
| | Location
Israel
|
Project
Development of Tryphophan Hydroxylase Inhibitors
College of Physicians and Surgeons
In the process of synthesizing chirale C compounds, several intermediates have been accumulated. They are being tested for their potention effects on serotoneric and adrenergic enzymes. . . . More »
| | Project Leader
Tamir, Hadassah
| | Location
Germany
|
Project
Genes de Meiose / lLeur Implication dans Sterilite chez L'homme
College of Physicians and Surgeons
DNA is collected from infertile men who are otherwise healthy and who have normal Y-chromosomes, as detected by an extensive series of micro-deletion analyses. These samples are then sequenced to . . . More »
| | Project Leader
Wolgemuth, Debra
| | Location
France
|
Project
Gene Therapy in Cancer
College of Physicians and Surgeons
Using the multiple-drug resistance gene to provide hematopoietic stem cells with resistance to chemiotherpeutic agents. Using retroviral gene-transfer technique developed at Columbia. Patients with . . . More »
| | Project Leader
Bank, Arthur
| | Location
United Kingdom
|
Project
Genetic Linkage Markers in Affective Disorders
College of Physicians and Surgeons
Search for linkage between DNA markers and affective disorders in a large series of Israeli pedigrees with high density of bipolar disorder. . . . More »
| | Project Leader
Baron, Miron
| | Location
Israel
|
Project
Genetic Modifications of Lipoprotein Lipase
College of Physicians and Surgeons
Studies to understand the functions of lipoprotein lipase, the rate-limiting enzyme for hydrolysis of plasma triglyceride. Genetically modified enzymes are studied in cells and mice. . . . More »
| | Project Leader
Goldberg, Ira
| | Location
Germany
|
Project
Genome Database
College of Physicians and Surgeons
Senior chromosome editor for human chromosome 13.
More »
| | Project Leader
Warburton, Dorothy
| | |
Project
Glucose-Transporters (Type 1) Deficiency
College of Physicians and Surgeons
DFG (Deutsche Forschungemeindscnaft), Dr. Daryl DeVivo. Glucose, an essential fuel for the brain, is transported into the brain via a glucose-transporter protein, GLUT-1. In the glucose . . . More »
| | | | Location
Germany
|
Project
Human Gene Therapy Project and Thalassemia Research Projects
College of Physicians and Surgeons
We have collaborated with Dr. Magio and his colleagues for many years on research projects involving thalassemia: (1) the role of human globin gene promoters in the expression of hybrid genes in . . . More »
| | Project Leader
Bank, Arthur
| | Location
Italy
|
Project
Hypersensitivity of Mammalian Cells to X-Rays at Low Doses of Radiation
College of Physicians and Surgeons
Earlier results indicated that the hypersensitivity of cells is greater at low doses (below 1Gy) of x-rays than at higher doses, due to the induction of repair processes at bigger doses. Of practical . . . More »
| | Project Leader
Hall, Eric
| | Location
United Kingdom
|
Project
IL-13 and IFNg: Regulators of Dendritic Cell Function in the Airways
College of Physicians and Surgeons
Interleukin (IL)-13 and Interferon (IFN)g are mediators made by T cells. IL-13 and IFNg play important roles in the pathogenesis of asthma. IL-13 induces many of the signs of asthma such as increased . . . More »
| | Project Leader
Grunig, Gabrielle
| | Location
Germany
|
Project
Interleukin-6 Cytokines and Heart Failure
College of Physicians and Surgeons
The project aims at elucidating the role of interleukin-6 cytokines in the pathophysiology of heart failure. . . . More »
| | Project Leader
Deng, Mario
| | Location
Germany
|
Project
Leadership Development in Biomedical Engineering
College of Physicians and Surgeons
Encourage undergraduate and graduate exchanges of biomedical-engineering students among participating institutions: Eindoven Technological University, The Netherlands; Hong Kong Polytechnic . . . More »
| | Project Leader
Mow, Van
| | Locations
Netherlands, Hong Kong, Japan, France, Switzerland
|
Project
Malignant Transformation of Human Bronchial Epithelial Cells by Tobacco Nitrosamine and Radon Alpha Particles
College of Physicians and Surgeons
To examine the cellular and molecular mechanisms of neoplastic transformation of immortalized human bronchial cells by the tobacco-specific nitrosamine NNK, either alone, or in combination with radon . . . More »
| | Project Leader
Hei, Tom K
| | Location
China
|
Project
Molecular Biology of Apoptosis in Human Cancer
College of Physicians and Surgeons
Molecular biology of apoptosis in human cancer. Investigation of defense mechanisms of human cancer against apoptosis. . . . More »
| | Project Leader
Sato, Taka-Aki
| | Location
Japan
|
Project
Molecular Biomarks of Carcinogen Exposure
Mailman School of Public Health
This project has evaluated the utility of biomarkers based on mutations in oncogenes and tumor suppressor genes in individuals exposed to carcinogen vinyl chloride in France. . . . More »
| | Project Leader
Brandt-Rauf, Paul
| | Location
France
|
Project
Molecular Genetics of Obesity and Type 2 Diabetes: France
College of Physicians and Surgeons
Current research activities include efforts to identify genes (and relevant allelic variants) related to obesity and/or type 2 diabetes in mice and humans. The lab has particular interest in the . . . More »
| | Project Leader
Leibel, Rudolph
| | Location
France
|
Project
Molecular Genetics of Obesity and Type 2 Diabetes: United Kingdom
College of Physicians and Surgeons
Current research activities include efforts to identify genes (and relevant allelic variants) related to obesity and/or type 2 diabetes in mice and humans. The lab has particular interest in the . . . More »
| | Project Leader
Leibel, Rudolph
| | Location
United Kingdom
|
Project
Molecular Mechanisms of Neural Induction
College of Physicians and Surgeons
A research program devoted to understanding the mechanisms of how the nervous system is established at the cellular and molecular level, using several model systems (Xenopus, chick, mouse) and . . . More »
| | Project Leader
Stern, Claudio
| | Location
United Kingdom
|
Project
Nuclear Envelope and Muscle Diseases: France
College of Physicians and Surgeons
The nuclear membranes and associated nuclear lamina network separate chromatin from the cytoplasmic compartment. Mutations in emerin, a transmembrane protein of the inner nuclear membrane, have been . . . More »
| | Project Leader
Worman, Howard
| | Location
France
|
Project
Nuclear Envelope and Muscle Diseases: Norway
College of Physicians and Surgeons
The goal of this project is to elucidate the mechanisms linking mutations in the ubiquitously expressed lamins A and C to a dysfunction of skeletal and cardiac muscles. This multidisciplinary project . . . More »
| | Project Leader
Worman, Howard
| | Location
Norway
|
Project
Regulation of Calcium Release Channels
College of Physicians and Surgeons
Characterize the structure and function of calcium-release channels that control muscle contraction. . . . More »
| | Project Leader
Marks, Andrew
| | Location
Slovakia
|
Project
Regulation of Lung Inflammation by Cell Calcium
College of Physicians and Surgeons
Regulation of lung inflammation by cell calcium
More »
| | Project Leader
Bhattacharya, Jahar
| | Location
Asia
|
Project
Remodeling of Gap Junction in Reentrant Circuits
College of Physicians and Surgeons
Immunolocalization of cerinexin 43 gap junction protein in arrhythmogenic regions of canine model of myocardial infarction. . . . More »
| | Project Leader
Wit, Andrew
| | Location
United Kingdom
|
Project
Role of PI3K/Akt Signaling Transduction in Higher Brain Function
College of Physicians and Surgeons
The PI3K/Akt kinase cascade in eukaryotic cells constitutes a pivotal signaling pathway involved in cell proliferation, cell survival, and metabolic cell responses. Recent studies have demonstrated . . . More »
| | Project Leader
Franke, Thomas
| | Locations
France, United Kingdom
|
Project
Structure and Function of Imprinted Gene Cluster on Chromosome 11p15/distal 7
College of Physicians and Surgeons
This is a collaborative grant involving four laboratories in four different countries to study the several aspects of genomic imprinting and imprinted genes. The emphasis is on the gene sequencing, . . . More »
| | Project Leader
Tycko, Benjamin
| | |
Project
The Function of the Mammalian Rad-9 Checkpoint Control Gene
College of Physicians and Surgeons
Investigating the function of human orthologenes at the fission yeast s. poumbe rad-9 checkpoint control gene. . . . More »
| | Project Leader
Lieberman, Howard
| | Location
Canada
|
Project
The Molecular Machinery That Activates Meiosis in Mammals
College of Physicians and Surgeons
The goal is to gain insight as to the molecular machinery that regulates entry into and progression through meiosis in mammals. Using mouse spermatogenesis as a model system, we are asking how the . . . More »
| | Project Leader
Wolgemuth, Debra
| | Location
Israel
|
Project
U.S.-Japan Cooperative Research Program in Carcinogenesis and Mutagenesis.
College of Physicians and Surgeons
Joint U.S.-Japan yearly workshops in mutagenesis and carcinogenesis and a scientist-exchange research program plus sharing of reagents and research materials. . . . More »
| | Project Leader
Weinstein, I
| | Location
Japan
|
